Blar i forfatter "Bendes, Annika"

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    • Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling 

      Dodig-Crnković, Tea; Hong, Mun-Gwan; Engel Thomas, Cecilia; Häussler, Ragna S.; Bendes, Annika; Dale, Matilda; Edfors, Fredrik; Forsström, Björn; Magnusson, Patrik K.E.; Schuppe-Koistinen, Ina; Odeberg, Jacob Olof; Fagerberg, Linn; Gummesson, Anders; Bergström, Göran; Mathias, Uhlén; Schwenk, Jochen M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-03)
      Background: Precision medicine approaches aim to tackle diseases on an individual level through molecular profiling. Despite the growing knowledge about diseases and the reported diversity of molecular phenotypes, the descriptions of human health on an individual level have been far less elaborate.<p> <p>Methods: To provide insights into the longitudinal protein signatures of well-being, we ...

    • Systematic development of sandwich immunoassays for the plasma secretome 

      Häussler, Ragna S.; Bendes, Annika; Iglesias, Maria Jesus; Sanchez-Rivera, Laura; Dodig‐Crnković, Tea; Byström, Sanna; Fredolini, Claudia; Birgersson, Elin; Dale, Matilda; Edfors, Fredrik; Fagerberg, Linn; Rockberg, Johan; Tegel, Hanna; Uhlén, Mathias; Qundos, Ulrika; Schwenk, Jochen M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-06)
      The plasma proteome offers a clinically useful window into human health. Recent advances from highly multiplexed assays now call for appropriate pipelines to validate individual candidates. Here, a workflow is developed to build dual binder sandwich immunoassays (SIA) and for proteins predicted to be secreted into plasma. Utilizing suspension bead arrays, ≈1800 unique antibody pairs are first screened ...